Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996–2014)
Identifieur interne : 000F18 ( Main/Exploration ); précédent : 000F17; suivant : 000F19Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996–2014)
Auteurs : Santiago Peralta [États-Unis] ; Boaz Arzi [États-Unis] ; Ana Nemec [États-Unis, Slovénie] ; Milinda J. Lommer [États-Unis] ; Frank J. M. Verstraete [États-Unis]Source :
- Frontiers in Veterinary Science [ 2297-1769 ] ; 2015.
Abstract
Osteonecrosis of the jaws (ONJ) is an entity of major clinical impact characterized by chronically exposed necrotic mandibular or maxillary bone. Its clinicopathological characteristics and possible inciting or risk factors are well described in humans but only anecdotally reported in dogs. Treatment modalities and outcome vary depending on the inciting factors involved and the extent and severity of the lesions. The objectives of this study were to retrospectively describe the clinicopathological features of non-radiation-related ONJ in a series of 14 dogs, identify possible inciting or risk factors, and report on the surgical treatment and outcome. For all patients, the medical records were used to collect information regarding signalment, clinical signs, characteristics of the oral, jaw and dental lesions, diagnostic imaging findings, histopathological and microbiological analysis, treatment performed, and outcome. The data collected showed that non-radiation-related ONJ appears to be an infrequent clinical entity but of significant impact in dogs; that a history of systemic antibiotics and dental disease is common among affected dogs; that previous dental extractions are commonly associated with ONJ sites; that using a systematic diagnostic approach is essential for diagnosis; and that thorough surgical debridement combined with a course of oral antibiotics was effective in the described dogs affected by advanced non-radiation-related ONJ.
Url:
DOI: 10.3389/fvets.2015.00007
PubMed: 26664936
PubMed Central: 4672176
Affiliations:
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Verstraete</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis</institution>,<addr-line>Davis, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Veterinary Science</title><idno type="eISSN">2297-1769</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Osteonecrosis of the jaws (ONJ) is an entity of major clinical impact characterized by chronically exposed necrotic mandibular or maxillary bone. Its clinicopathological characteristics and possible inciting or risk factors are well described in humans but only anecdotally reported in dogs. Treatment modalities and outcome vary depending on the inciting factors involved and the extent and severity of the lesions. The objectives of this study were to retrospectively describe the clinicopathological features of non-radiation-related ONJ in a series of 14 dogs, identify possible inciting or risk factors, and report on the surgical treatment and outcome. For all patients, the medical records were used to collect information regarding signalment, clinical signs, characteristics of the oral, jaw and dental lesions, diagnostic imaging findings, histopathological and microbiological analysis, treatment performed, and outcome. The data collected showed that non-radiation-related ONJ appears to be an infrequent clinical entity but of significant impact in dogs; that a history of systemic antibiotics and dental disease is common among affected dogs; that previous dental extractions are commonly associated with ONJ sites; that using a systematic diagnostic approach is essential for diagnosis; and that thorough surgical debridement combined with a course of oral antibiotics was effective in the described dogs affected by advanced non-radiation-related ONJ.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Almazrooa, Sa" uniqKey="Almazrooa S">SA Almazrooa</name></author><author><name sortKey="Woo, Sb" uniqKey="Woo S">SB Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Poznak, C" uniqKey="Van Poznak C">C Van Poznak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magremanne, M" 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Lommer</name><name sortKey="Lommer, Milinda J" sort="Lommer, Milinda J" uniqKey="Lommer M" first="Milinda J." last="Lommer">Milinda J. Lommer</name><name sortKey="Nemec, Ana" sort="Nemec, Ana" uniqKey="Nemec A" first="Ana" last="Nemec">Ana Nemec</name><name sortKey="Verstraete, Frank J M" sort="Verstraete, Frank J M" uniqKey="Verstraete F" first="Frank J. M." last="Verstraete">Frank J. M. Verstraete</name></country><country name="Slovénie"><noRegion><name sortKey="Nemec, Ana" sort="Nemec, Ana" uniqKey="Nemec A" first="Ana" last="Nemec">Ana Nemec</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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